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Reading is fundamental

2023

Firpo et al. PLoS Pathogens. Polyamines and eIF5A hypusination facilitate SREBP2 synthesis and cholesterol production leading to enhanced enterovirus attachment and infection

Mastrodomenico et al. mSphere. Persistent Coxsackievirus B3 infection in pancreatic ductal cells in vitro downregulates cellular polyamine metabolism.

Marreiros et al. Communications Biology A non-canonical sensing pathway mediates Plasmodium adaptation to amino acid deficiency.

Cruz-Pulido and Mounce. Seminars in Cellular and Developmental Biology. Good cop, bad cop: Polyamines play both sides in host immunity and viral replication.

2022

Mastrodomenico et al. ACS Infectious Diseases. Polyamine-Linked Cholesterol Incorporation in Rift Valley Fever Virus Particles Promotes Infectivity.

LoMascolo et al. Antimicrobial Agents and Chemotherapy. Bisacodyl Limits Chikungunya Virus Replication In Vitro and Is Broadly Antiviral.

2021

Firpo et al. bioRxiv. Polyamines and eIF5A hypusination facilitate SREBP2 translation and cholesterol synthesis to enhance enterovirus attachment and infection.

Hulsebosch et al. bioRxiv. Polyamines mediate enterovirus attachment directly and indirectly through cellular heparan sulfate synthesis

Drayman et al. Science. Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.

Hulsebosch et al. Viruses. Polyamine analog diethylnorspermidine restricts Coxsackievirus B3 and is overcome by 2A protease mutation in vitro.

2020

Firpo et al. ACS Infectious Diseases. Targeting polyamines inhibits coronavirus infection by reducing cellular attachment

Mastrodomenico et al. ACS Infectious Diseases. Virion-Associated Polyamines Transmit with Bunyaviruses to Maintain Infectivity and Promote Entry.

Firpo et al. Biomolecules. Diverse functions of polyamines in virus infection.

Sandler et al. Antimicrobial Agents and Chemotherapy. Novel ionophores active against La Crosse virus identified through rapid antiviral screening.

López et al. Journal of Virology. High-throughput fluorescence-based screen identifies the neuronal microRNA miR-124 as a positive regulator of alphavirus Minfection.

2019

Tate et al. Cell Reports. Ribavirin induces polyamine depletion via nucleotide depletion to limit virus replication.

Kicmal et al. Journal of Virology. Polyamine depletion abrogates enterovirus cellular attachment.

Dial et al. Viruses. Coxsackievirus B3 responses to polyamine depletion via enhancement of 2A and 3C protease activity.

Mastrodomenico et al. Journal of Virology. Polyamine depletion inhibits bunyavirus infection via generation of noninfectious interfering viruses.

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