
Reading Is Fundamental
Discoveries don't end when an experiment is finished—they begin when they're shared. We strive to publish rigorous, impactful science while helping every trainee become a thoughtful scientific writer, presenter, and communicator. Our goal is to prepare the next generation of scientists not only to make discoveries, but to tell their stories well.
2026
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LoMascolo et al. Journal of Virology. Lysophosphatidic acid promotes lipid metabolism through AMPK signaling to support Coxsackie virus infection
2025
2024
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Villanueva Guzman, et al. ACS Infectious Diseases. Rapid Screening to Identify Antivirals against Persistent and Acute Coxsackievirus B3 Infection.
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Cruz-Pulido, LoMascolo et al.PLoS Pathogens. Polyamines mediate cellular energetics and lipid metabolism through mitochondrial respiration to facilitate virus replication
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Tate et al. ACS Infectious Diseases. Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity
2023
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Firpo et al. PLoS Pathogens. Polyamines and eIF5A hypusination facilitate SREBP2 synthesis and cholesterol production leading to enhanced enterovirus attachment and infection
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Mastrodomenico et al. mSphere. Persistent Coxsackievirus B3 infection in pancreatic ductal cells in vitro downregulates cellular polyamine metabolism
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Marreiros et al. Communications Biology A non-canonical sensing pathway mediates Plasmodium adaptation to amino acid deficiency
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Cruz-Pulido and Mounce. Seminars in Cellular and Developmental Biology. Good cop, bad cop: Polyamines play both sides in host immunity and viral replication
2022
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Mastrodomenico et al. ACS Infectious Diseases. Polyamine-Linked Cholesterol Incorporation in Rift Valley Fever Virus Particles Promotes Infectivity
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LoMascolo et al. Antimicrobial Agents and Chemotherapy. Bisacodyl Limits Chikungunya Virus Replication In Vitro and Is Broadly Antiviral
2021
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Firpo et al. bioRxiv. Polyamines and eIF5A hypusination facilitate SREBP2 translation and cholesterol synthesis to enhance enterovirus attachment and infection.
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Hulsebosch et al. bioRxiv. Polyamines mediate enterovirus attachment directly and indirectly through cellular heparan sulfate synthesis
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Drayman et al. Science. Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.
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Hulsebosch et al. Viruses. Polyamine analog diethylnorspermidine restricts Coxsackievirus B3 and is overcome by 2A protease mutation in vitro.
2020
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Firpo et al. ACS Infectious Diseases. Targeting polyamines inhibits coronavirus infection by reducing cellular attachment
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Mastrodomenico et al. ACS Infectious Diseases. Virion-Associated Polyamines Transmit with Bunyaviruses to Maintain Infectivity and Promote Entry
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Firpo et al. Biomolecules. Diverse functions of polyamines in virus infection
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Sandler et al. Antimicrobial Agents and Chemotherapy. Novel ionophores active against La Crosse virus identified through rapid antiviral screening
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López et al. Journal of Virology. High-throughput fluorescence-based screen identifies the neuronal microRNA miR-124 as a positive regulator of alphavirus Minfection
2019
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Tate et al. Cell Reports. Ribavirin induces polyamine depletion via nucleotide depletion to limit virus replication
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Kicmal et al. Journal of Virology. Polyamine depletion abrogates enterovirus cellular attachment
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Dial et al. Viruses. Coxsackievirus B3 responses to polyamine depletion via enhancement of 2A and 3C protease activity
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Mastrodomenico et al. Journal of Virology. Polyamine depletion inhibits bunyavirus infection via generation of noninfectious interfering viruses